Conductivity Variation during Irreversible Electroporation

Irreversible electroporation (IRE) is an emerging tumour ablation technique, which utilizes non thermoelectric pulse to ablate tumours. Compared with the common treatment methods, e.g., surgery, chemotherapy and radiotherapy, IRE has advantages of short action time, no massive bleeding tissue during ablation, avoiding heat sink effect, etc. However, process will be affected by distribution E-field tissue. The major factors affect are parameters electrical characteristics tissue, conductivity We utilized finite element analysis software COMSOL Multiphysics 5.4 calculate variation in liver IRE. In this study, there a Low-Voltage High-Frequency (LVHF) involves 3500 unipolar bipolar pulses, High-Voltage Low-Frequency (HVLF) eight pulses. results show that change HVLF higher than LVHF due strength E-field. most important conclusion can only near electrode tip. significantly between electrodes.